Adjuvant antitumour treatment
Research suggests that the use of hyperbaric therapy (HBOT) in conjunction with radiotherapy or chemotherapy can have significant results in reducing mortality and relapses. HBOT can help treat cancer in several ways, such as improving blood flow to the tumour, slowing the growth of cancer cells (especially hypoxic cancer cells, which are low in oxygen) and increasing the effectiveness of standard therapy.
HBOT may also help reduce the side effects of cancer treatment, such as nausea, vomiting and fatigue.
Kamonwan Jenwitheesuk, Ajanee Mahakkanukrauh, Wiyada Punjaruk, Kriangsak Jenwitheesuk, Bowornsilp Chowchuen, Suthin Jinaporntham, Krittinant Uraiwan, and Phasuk Limrattanapimpa
Efficacy of Adjunctive Hyperbaric Oxygen Therapy in Osteoradionecrosis6 Oct 2018; https://doi.org/10.1089/biores.2018.0019
Marilot C T Batenburg, Wies Maarse, Femke van der Leij, Inge O Baas, Onno Boonstra, Nina Lansdorp, Annemiek Doeksen, Desiree H J G van den Bongard, Helena M Verkooijen
The impact of hyperbaric oxygen therapy on late radiation toxicity and quality of life in breast cancer patientsBreast Cancer Res Treat 2021 Sep;189(2):425-433; DOI: 10.1007/s10549-021-06332-2
Mehmet Salih İyikesici, Abdul Kadir Slocum, Nasha Winters, Miriam Kalamian, and Thomas N Seyfried
Metabolically Supported Chemotherapy for Managing End-Stage Breast Cancer: A Complete and Durable ResponseCureus. 2021 Apr; 13(4): e14686; Published online 2021 Apr 26; DOI: 10.7759/cureus.14686; PMCID: PMC8072186; PMID: 33927959
Nicole E Spruijt and Roy van den Berg
The effect of hyperbaric oxygen treatment on late radiation tissue injury after breast cancer: A case-series of 67 patientsDiving Hyperb Med. 2020 Sep; 50(3): 206–213; Published online 2020 Sep 30. doi: 10.28920/dhm50.3.206-213; PMCID: PMC7819722; PMID: 32957121
Changlin Qian, Hua Liu, Jie Zhang, Zhiyong Shen
The efficacy and tolerance of high pressure oxygen combined with chemotherapy in postoperative patients with advanced gastric cancerDOI: 10.21037/tcr.2018.04.16
Mehmet Salih İyikesici, Abdul Kadir Slocum, Ayshe Slocum, Ferhan Bulent Berkarda, Miriam Kalamian, Thomas N. Seyfried
Efficacy of Metabolically Supported Chemotherapy Combined with Ketogenic Diet, Hyperthermia, and Hyperbaric Oxygen Therapy for Stage IV Triple-Negative Breast CancerDOI: 10.7759/cureus.1445
Diogo Alpuim Costa, Mafalda Sampaio-Alves, Eduardo Netto, Gonçalo Fernandez, Edson Oliveira, Andreia Teixeira, Pedro Modas Daniel, Guilherme Silva Bernardo, and Carla Amaro
Hyperbaric Oxygen Therapy as a Complementary Treatment in Glioblastoma—A Scoping ReviewFront Neurol. 2022; 13: 886603; Published online 2022 Jul 1. doi: 10.3389/fneur.2022.886603; PMCID: PMC9283648; PMID: 35847231
Renée Helmers MD, DDS, Dan M. J. Milstein DDS, PhD, Nina F. Straat, Arash Navran MD, David N. Teguh MD, PhD, Robert A. van Hulst MD, PhD, Ludi E. Smeele MD, DDS, PhD, Jan de Lange MD, DDS, PhD
The impact of hyperbaric oxygen therapy on late irradiation injury in oral microcirculationHead & NeckVolume 44, Issue 7 p. 1646-1654; https://doi.org/10.1002/hed.27073
Michael H Bennett, John Feldmeier, Robert Smee, Christopher Milross
Hyperbaric oxygenation for tumour sensitisation to radiotherapyhttps://doi.org/10.1002/14651858.CD005007.pub4
E.L.Meier, D.R.Mink van der Molen, C.A.Lansdorp, M.C.T.Batenburg, F.van der Leij, H.M.Verkooijen, O.Boonstra, S.Hummelink, D.J.O.Ulrich
Hyperbaric oxygen therapy for local late radiation toxicity in breast cancer patients: A systematic reviewhttps://doi.org/10.1016/j.breast.2022.12.009
Lei Huang, M.D., Warren Boling, and John H. Zhang
Hyperbaric oxygen therapy as adjunctive strategy in treatment of glioblastoma multiformeMed Gas Res. 2018 Jan-Mar; 8(1): 24–28; Published online 2018 Apr 18. doi: 10.4103/2045-9912.229600; PMCID: PMC5937300; PMID: 29770193
Qi-Zhong Lu, Xiang Li, Jun Ouyang, Jin-Quan Li and Gang Chen
Further application of hyperbaric oxygen in prostate cancerMed Gas Res. 2018 Oct-Dec; 8(4): 167–171; Published online 2019 Jan 9. DOI: 10.4103/2045-9912.248268; PMCID: PMC6352573; PMID: 30713670
Kristine Yttersian Sletta, Maria K Tveitarås, Ning Lu, Agnete S T Engelsen, Rolf K Reed, Annette Garmann-Johnsen, Linda Stuhr
Oxygen-dependent regulation of tumor growth and metastasis in human breast cancer xenograftsPLoS One. 2017 Aug 23;12(8):e0183254; DOI: 10.1371/journal.pone.0183254; eCollection 2017.
Wojciech Polom, Alicja Klejnotowska, Marcin Matuszewski, Zdzislaw Sicko, Marcin Markuszewski, Kazimierz Krajka
Hyperbaric oxygen therapy (HBOT) in case of hemorrhagic cystitis after radiotherapyPMID: 24578962; PMCID: PMC3921805; DOI: 10.5173/ceju.2012.04.art4
Gonca Hanedan Uslu, Gamze Çebi, Bengü Çobanoğlu
Hyperbaric oxygen therapy in the treatment of complications of irradiation in laryngeal cancerPMID: 30455593; PMCID: PMC6238093; DOI: 10.5114/wo.2018.78945
Makoto Endoh, Hiroyuki Oizumi, Hirohisa Kato, Jun Suzuki, Hikaru Watarai, Akira Hamada, Katsuyuki Suzuki, Kenta Nakahashi, Satoshi Shiono, Mitsuaki Sadahiro
Hyperbaric oxygen therapy for postoperative ischemic bronchitis after resection of lung cancerPMID: 30622789; PMCID: PMC6297444; DOI: 10.21037/jtd.2018.10.45
Karan Pandey, David N Teguh, Robert A van Hulst
Effect of hyperbaric oxygen treatment on skin elasticity in irradiated patientsPMID: 36100932; PMCID: PMC9722336 (available on 2023-09-30); DOI: 10.28920/dhm52.3.208-212
Nadine I. Geldof, Rob A. van Hulst, Milan L. Ridderikhof, and David N. Teguh
Hyperbaric oxygen treatment for late radiation-induced tissue toxicity in treated gynaecological cancer patients: a systematic reviewRadiat Oncol. 2022; 17: 164; Published online 2022 Oct 6. DOI: 10.1186/s13014-022-02067-6
Assist. Prof. Jernej Vidmar, M.D., Ph.D., Ksenija Cankar, Maja Groselj, Zarko Finderle, and Igor Sersa
Assessment of Hyperbaric Oxygenation Treatment Response in Parotid Glands By T2 Mapping Following Radiotherapy for Head and Neck TumoursRadiol Oncol. 2022 Mar; 56(1): 60–68; Published online 2022 Feb 11. doi: 10.2478/raon-2022-0001; PMCID: PMC8884852; PMID: 35148472
Shao-Yuan Chen, Koichi Tsuneyama, Mao-Hsiung Yen, Jiunn-Tay Lee, Jiun-Liang Chen, and Shih-Ming Huang
Hyperbaric oxygen suppressed tumor progression through the improvement of tumor hypoxia and induction of tumor apoptosis in A549-cell-transferred lung cancerSci Rep. 2021; 11: 12033; Published online 2021 Jun 8; DOI: 10.1038/s41598-021-91454-2
Jasmijn D. Generaal, Corine A. Lansdorp, Onno Boonstra, Barbara L. van Leeuwen, Hubertus A. M. Vanhauten, Marc G. Stevenson, Lukas B. Been
Hyperbaric oxygen therapy for radiation-induced tissue injury following sarcoma treatment: A retrospective analysis of a Dutch cohortPublished: June 8, 2020; https://doi.org/10.1371/journal.pone.0234419
Luiz Henrique Ferreira Júnior, Pedro Henrique Justino Oliveira Limirio, Priscilla Barbosa Ferreira Soares, Paula Dechichi, Letícia de Souza Castro Filice, Paulo Sérgio Quagliatto & Flaviana Soares Rocha
The effect of hyperbaric oxygen therapy on bone macroscopy, composition and biomechanical properties after ionizing radiation injuryRadiation Oncology volume 15, Article number: 95 (2020)
Nadine I. Geldof, Rob A. van Hulst, Milan L. Ridderikhof & David N. Teguh
Hyperbaric oxygen treatment for late radiation-induced tissue toxicity in treated gynaecological cancer patients: a systematic reviewRadiation Oncology volume 17, Article number: 164 (2022)
Michael H Bennett, John Feldmeier, Neil B Hampson, Robert Smee, Christopher Milross
Hyperbaric oxygen therapy for late radiation tissue injuryVersion published: 28 April 2016; https://doi.org/10.1002/14651858.CD005005.pub4
Jeffrey S. Cooper; Mary E. Hanley; Stephen Hendriksen; Marc Robins
Hyperbaric Treatment Of Delayed Radiation InjuryPMID: 29261879
Mehdi Ouaïssi, Stephanie Tran, Diane Mege, Vivien Latrasse, Alain Barthelemy, Nicolas Pirro, Philippe Grandval, James Lassey, Igor Sielezneff, Bernard Sastre, and Mathieu Coulange
Pelvic Radiation Disease Management by Hyperbaric Oxygen Therapy: Prospective Study of 44 PatientsGastroenterol Res Pract. 2014; 2014: 108073; Published online 2014 Jan 27. DOI: 10.1155/2014/108073; PMCID: PMC3922018; PMID: 24592276
Nicklas Oscarsson, Bernd Müller, Anders Rosén, Pär Lodding, Johan Mölne, Daniel Giglio, Karin M Hjelle, MD, Guro Vaagbø, Ole Hyldegaard, Michael Vangedal, Lisbeth Salling, Anders Kjellberg, Folke Lind, Otto Ettala, Olli Arola, Helén Seeman-Lodding
Radiation-induced cystitis treated with hyperbaric oxygen therapy (RICH-ART): a randomised, controlled, phase 2–3 trialPublished:September 16, 2019, DOI:https://doi.org/10.1016/S1470-2045(19)30494-2
Neil B. Hampson, James R. Holm, Claude E. Wreford-Brown, John Feldmeier
Prospective assessment of outcomes in 411 patients treated with hyperbaric oxygen for chronic radiation tissue injuryCancerVolume 118, Issue 15 p. 3860-3868, https://doi.org/10.1002/cncr.26637
A. Vera- Rosas, D. Aguiar, A. Domínguez, A. Cabrera- Vicente, P. Martín- Barrientos, R. Cabrera, B.G. Salas-Salas, L. Ferrera- Alayón, I. Ribeiro, R. Chicas-Sett, P.C. Lara, M. Lloret
Prospective Pilot study of Quality of Life in patients with severe late-radiation-toxicity treated by Low hyperbaric-oxigen-therapyPublished:March 27, 2023DOI:https://doi.org/10.1016/j.ctro.2023.100620
K Kohshi, Y Kinoshita, H Imada, N Kunugita, H Abe, H Terashima, N Tokui, and S Uemura
Effects of radiotherapy after hyperbaric oxygenation on malignant gliomasBr J Cancer. 1999 Apr; 80(1-2): 236–241, doi: 10.1038/sj.bjc.6690345, PMCID: PMC2363018, PMID: 10390002
Karuppaiyah Selvendiran, M Lakshmi Kuppusamy, Shabnam Ahmed, Anna Bratasz, Guruguhan Meenakshisundaram, Brian K Rivera, Mahmood Khan, Periannan Kuppusamy
Oxygenation inhibits ovarian tumor growth by downregulating STAT3 and cyclin-D1 expressionsPMID: 20562529 DOI: 10.4161/cbt.10.4.12448
Yasuomi Kawasoe Masahiro Yokouchi Yoshinori Ueno Hiroaki Iwaya Hiroki Yoshida Setsuro Komiya
Hyperbaric oxygen as a chemotherapy adjuvant in the treatment of osteosarcomaPublished online on: November 1, 2009 https://doi.org/10.3892/or_00000534
Jurstine Daruwalla B.Sc & Chris Christophi MD
Hyperbaric Oxygen Therapy for Malignancy: A ReviewPublished: 07 November 2006, volume 30, pages2112–2131 (2006)
Kazuhiko Ogawa, M.D., Shogo Ishiuchi, M.D., Osamu Inoue, M.D., Yoshihiko Yoshii, M.D., Atsushi Saito, M.D., Takashi Watanabe, M.D., Shiro Iraha, M.D., Takafumi Toita, M.D., Yasumasa Kakinohana, Ph.D., Takuro Ariga, M.D., Goro Kasuya, M.D., Sadayuki Murayama, M.D.
Phase II Trial of Radiotherapy After Hyperbaric Oxygenation With Multiagent Chemotherapy (Procarbazine, Nimustine, and Vincristine) for High-Grade Gliomas: Long-Term ResultsPublished:March 21, 2011DOI:https://doi.org/10.1016/j.ijrobp.2010.12.070
Kiyotaka Kohshi, Haruaki Yamamoto, Ai Nakahara, Takahiko Katoh & Masashi Takagi
Fractionated stereotactic radiotherapy using gamma unit after hyperbaric oxygenation on recurrent high-grade gliomasCLINICAL-PATIENT STUDIES, Published: 22 November 2006, volume 82, pages297–303 (2007)
K Ogawa, Y Yoshii, O Inoue, T Toita, A Saito, Y Kakinohana, G Adachi, S Iraha, W Tamaki, K Sugimoto, A Hyodo, and S Murayama
Phase II trial of radiotherapy after hyperbaric oxygenation with chemotherapy for high-grade gliomasBr J Cancer. 2006 Oct 9; 95(7): 862–868., Published online 2006 Sep 5. doi: 10.1038/sj.bjc.6603342, PMCID: PMC2360529, PMID: 16953239
Pei Wang, Xiao-Yan Wang, Chang-Feng Man, Dan-Dan Gong, Yu Fan
Advances in hyperbaric oxygen to promote immunotherapy through modulation of the tumor microenvironmentFront. Oncol., 15 September 2023. Sec. Cancer Immunity and Immunotherapy, Volume 13 - 2023 | https://doi.org/10.3389/fonc.2023.1200619
Diogo Alpuim Costa, J. Guilherme Gonçalves-Nobre, Mafalda Sampaio-Alves, Nuno Guerra, Joana Arana Ribeiro, Carla Espiney Amaro
Hyperbaric oxygen therapy as a complementary treatment in neuroblastoma — a narrative reviewFront. Oncol., 26 September 2023, Sec. Pediatric Oncology, Volume 13 - 2023 | https://doi.org/10.3389/fonc.2023.1254322
Yun Mukmin Akbar, Santika Nuroktapiani, Sri Tjahajawati, Suhardjo Sitam, Amaliya Amaliya, Ani Melani Maskoen, Endah Mardiati, Ganesha Wandawa
The Role of Hyperbaric Oxygen Therapy on the Management of Mandibular Osteoradionecrosis: A Scoping ReviewJournal of International Dental and Medical Research ISSN 1309-100X, Volume 16, Number 4 2023
Dieuwke R. Mink van der Molen, PhD; Marilot C. T. Batenburg, MD, PhD; Wiesje Maarse, MD, PhD; Desiree H. J. G. van den Bongard, MD, PhD; Annemiek Doeksen, MD, PhD; Marjoleine Y. de Lange, MD; Carmen C. van der Pol, MD; Daniel J. Evers, MD, PhD; Corine A. Lansdorp, MD, PhD; Jacco van der Laan, Peter M. van de Ven, MD, PhD; Femke van der Leij, MD, PhD; Helena M. Verkooijen, MD, PhD
Hyperbaric Oxygen Therapy and Late Local Toxic Effects in Patients With Irradiated Breast Cancer - A Randomized Clinical TrialJAMA Oncol. Published online February 8, 2024. doi:10.1001/jamaoncol.2023.6776
Bardia Hajikarimloo, Shahin Kavousi, Ghazaleh Ghaffaripour Jahromi, Mahdi Mehmandoost, Saeed Oraee-Yazdani, Farzan Fahim
Hyperbaric oxygen therapy as an alternative therapeutic option for radiation-induced necrosis following radiotherapy for intracranial pathologiesVersion published: 28 April 2016; https://doi.org/10.1002/14651858.CD005005.pub4
Shigeo Yamada, Yoshiyuki Fukugawa, Takahiro Otsuka, Tetsuo Saito, Natsuo Oya
Radiation-Induced Myonecrosis: A Case Report of a Cervical Cancer Patient With a History of Systemic Lupus ErythematosusPublished: February 28, 2024; DOI: 10.7759/cureus.55134
Zi-Heng Li, Xinping Zhang, Fu-Gen Wu
Hyperbaric Oxygen-Facilitated Cancer Treatment: A MinireviewFirst published: 10 March 2024, https://doi.org/10.1002/anbr.202300162
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