Chronic infections
Numerous studies highlight the importance of hyperbaric therapy in the treatment of chronic infections and especially infections with limited response to conventional treatments. Some of the most common chronic infections that can be treated with hyperbaric therapy are osteomyelitis, osteitis, osteodiscitis, soft tissue infections (open wounds or burns), inner ear infections, lung infections, skin infections (abscesses or ulcers), and borreliosis.
Hyperbaric oxygen therapy can contribute to the healing of infections through direct bacteriostatic or bactericidal effects, enhancement of the antimicrobial effects of the immune system and additive or synergistic effects with certain antimicrobial agents.
B. Devaney, G. Frawley, L. Frawley, D. V. Pilcher
Necrotising soft tissue infections: the effect of hyperbaric oxygen on mortalityAnaesth Intensive Care 2015 | 43:6
David Wilkinson, FANZCA; David Doolette, PhD
Hyperbaric Oxygen Treatment and Survival From Necrotizing Soft Tissue InfectionArch Surg. 2004;139(12):1339-1345; DOI:10.1001/archsurg.139.12.1339
Morten Hedetoft, Michael H Bennett, and Ole Hyldegaard
Adjunctive hyperbaric oxygen treatment for necrotising soft-tissue infections: A systematic review and meta-analysisDiving Hyperb Med. 2021 Mar; 51(1): 34–43; Published online 2021 Mar 31. DOI: 10.28920/dhm51.1.34-43; PMCID: PMC8081587; PMID: 33761539
Pedro Valente Aguiar, Bruno Carvalho, Pedro Monteiro, Paulo Linhares, Óscar Camacho, and Rui Vaz
Hyperbaric oxygen treatment: Results in seven patients with severe bacterial postoperative central nervous system infections and refractory mucormycosisDiving Hyperb Med. 2021 Mar; 51(1): 86–93; Published online 2021 Mar 31. doi: 10.28920/dhm51.1.86-93; PMCID: PMC8313776; PMID: 33761547
Lawrence A Delasotta, Andrew Hanflik, Griffin Bicking, William J Mannella
Hyperbaric Oxygen for Osteomyelitis in a Compromised HostDOI: 10.2174/1874325001307010114
Pradeoth Mukundan Korambayil, Prashanth Varkey Ambookan, Rameela Ravindran Karangath
Necrotising soft-tissue infections with hyperbaric oxygen therapy as an adjunct: A tertiary care experienceDOI: 10.4103/JCSR.JCSR_84_19
Christian Johann Lerche, Franziska Schwartz, Mia Marie Pries-Heje, Emil Loldrup Fosbøl, Kasper Iversen, Peter Østrup Jensen, Niels Høiby, Ole Hyldegaard, Henning Bundgaard, and Claus Moser
Potential Advances of Adjunctive Hyperbaric Oxygen Therapy in Infective EndocarditisFront Cell Infect Microbiol. 2022; 12: 805964; Published online 2022 Feb 3. DOI: 10.3389/fcimb.2022.805964; PMCID: PMC8851036; PMID: 35186793
Morten Hedetoft, Peter Østrup Jensen, Claus Moser, Julie Vinkel, Ole Hyldegaard
Hyperbaric oxygen treatment impacts oxidative stress markers in patients with necrotizing soft-tissue infectionhttp://orcid.org/0000-0002-2606-8041
Mohammad Yousef Memar, Mina Yekani, Naser Alizadeh, Hossein Bannazadeh Baghi
Hyperbaric oxygen therapy: Antimicrobial mechanisms and clinical application for infectionshttps://doi.org/10.1016/j.biopha.2018.10.142
C.J. Lerche, L.J. Christophersen, M. Kolpen, P.R. Nielsen, H. Trøstrup, K. Thomsen, O. Hyldegaard, H. Bundgaard, P.Ø. Jensen, N. Høiby, C. Moser
Hyperbaric oxygen therapy augments tobramycin efficacy in experimental Staphylococcus aureus endocarditishttps://doi.org/10.1016/j.ijantimicag.2017.04.025
Chiara Gardin, Gerardo Bosco, Letizia Ferroni, Silvia Quartesan, Alex Rizzato, Marco Tatullo and Barbara Zavan
Hyperbaric Oxygen Therapy Improves the Osteogenic and Vasculogenic Properties of Mesenchymal Stem Cells in the Presence of Inflammation In VitroInt. J. Mol. Sci. 2020, 21(4), 1452; https://doi.org/10.3390/ijms21041452
Wen-Kuang Yu, Yen-Wen Chen, Huei-Guan Shie, Te-Cheng Lien, Hsin-Kuo Kao & Jia-Horng Wang
Hyperbaric oxygen therapy as an adjunctive treatment for sternal infection and osteomyelitis after sternotomy and cardiothoracic surgeryJournal of Cardiothoracic Surgery volume 6, Article number: 141 (2011)
Olga Savvidou, Angelos Kaspiris, Ioanna K Bolia, George D Chloros
Effectiveness of Hyperbaric Oxygen Therapy for the Management of Chronic Osteomyelitis: A Systematic Review of the LiteratureJuly 2018Orthopedics 41(4):193-199; DOI:10.3928/01477447-20180628-02
Chin-En Chen, Shu-Tai Shih, Te-Hu Fu, Jun-Wen Wang, Ching-Jen Wang
Hyperbaric oxygen therapy in the treatment of chronic refractory osteomyelitis: a preliminary reportPMID: 12718388
Mary E. Hanley; Stephen Hendriksen; Jeffrey S. Cooper
Hyperbaric Treatment Of Chronic Refractory OsteomyelitisPMID: 28613536
Prashanth Lowell Monis, Venkatraman Bhat, Samarth Shetty, Paul Christadas Salins
Hyperbaric Oxygen Therapy in the Management of Zygomatic Bone OsteomyelitisPMID: 34408368 PMCID: PMC8313621 DOI: 10.1007/s12663-020-01469-x
Assen Mladenov, Katharina Diehl, Oliver Müller, Christian von Heymann, Susanne Kopp, Wiebke K Peitsch
Outcome of necrotizing fasciitis and Fournier's gangrene with and without hyperbaric oxygen therapy: a retrospective analysis over 10 yearsPMID: 35932075; PMCID: PMC9356491; DOI: 10.1186/s13017-022-00448-6
Julie Vinkel, Leonor Rib, Alfonso Buil, Morten Hedetoft, Ole Hyldegaard
Investigating the Effects of Hyperbaric Oxygen Treatment in Necrotizing Soft Tissue Infection With Transcriptomics and Machine Learning (the HBOmic Study): Protocol for a Prospective Cohort Study With Data ValidationPublished on 25.11.2022 in Vol 11 , No 11 (2022) :November
Christian Johann Lerche, Franziska Schwartz, Marie Theut, Emil Loldrup Fosbøl, Kasper Iversen, Henning Bundgaard, Niels Høiby and Claus Moser
Anti-biofilm Approach in Infective Endocarditis Exposes New Treatment Strategies for Improved Outcomepublished: 18 June 2021; DOI: 10.3389/fcell.2021.643335
Joshua J. Shaw, Charles Psoinos, Timothy A. Emhoff, Shimul A. Shah, and Heena P. Santry
Not Just Full of Hot Air: Hyperbaric Oxygen Therapy Increases Survival in Cases of Necrotizing Soft Tissue InfectionsSurg Infect (Larchmt). 2014 Jun 1; 15(3): 328–335; DOI: 10.1089/sur.2012.135; PMCID: PMC4696431; PMID: 24786980
M. Schmale ,A Fichtner ,C Pohl ,E.John &M Bucher
Hyperbaric oxygenation in necrotizing soft tissue infections: ProThe surgeon volume 83 , pages973-979 ( 2012 )
Zdravko Roje, Željka Roje, Dario Matić, Davor Librenjak, Stjepan Dokuzović & Josip Varvodić
Necrotizing fasciitis: literature review of contemporary strategies for diagnosing and management with three case reports: torso, abdominal wall, upper and lower limbSWorld Journal of Emergency Surgery volume 6, Article number: 46 (2011)
Barbara Wójcik, Jerzy Superata, Tomasz Tuleja, Ewa Kobielska, Zbigniew Szyguła
Advances in Management of Fournier’s Gangrene by Coupling Intensive Hospital Treatment With Innovative Post-discharge Hyperbaric Oxygen Therapy Rehabilitation: A Case ReportPublished: March 24, 2023, DOI: 10.7759/cureus.36639
Şefika Körpınar
Could Hyperbaric Oxygen Be a Solution in the Treatment of Spinal Infections?Medicina (Kaunas). 2019 May; 55(5): 164 Published online 2019 May 20. doi: 10.3390/medicina55050164; PMCID: PMC6571771; PMID: 31137457
Elsa Goerger, Estelle Honnorat, Hélène Savini, Mathieu Coulange, Eric Bergmann, Fabrice Simon, Piseth Seng, and Andreas Stein
Anti-infective therapy without antimicrobials: Apparent successful treatment of multidrug resistant osteomyelitis with hyperbaric oxygen therapyIDCases. 2016; 6: 60–64; Published online 2016 Sep 28; doi: 10.1016/j.idcr.2016.09.008; PMCID: PMC5053032; PMID: 27713861
Dingzi Zhou, Daigang Fu, Ling Yan and Linshen Xie
The Role of Hyperbaric Oxygen Therapy in the Treatment of Surgical Site Infections: A Narrative ReviewMedicina 2023, 59(4), 762; https://doi.org/10.3390/medicina59040762
Chi-Tai Lee, Tzu-Han Hsieh, Chan-Ching Chu, Yung-Ray Hsu, Jia-Horng Wang, Jia-Kang Wang, Zhanqi Zhao and Hou-Tai Chang
Hyperbaric oxygen therapy as rescue therapy for pediatric frosted branch angiitis with Purtscher-like retinopathy: A case reportFront. Med., 17 April 2023; Sec. Ophthalmology; Volume 10 - 2023 | https://doi.org/10.3389/fmed.2023.1119623
Manish Raj, Raj K. Bhartiya, Ajay K. Rajput, Santosh Kumar Singh, Jitendra Pal Singh Jadon, S. P. S. Gill
Hyperbaric Oxygen Therapy for Soft Tissue Injury in Open Musculoskeletal Trauma: A Prospective StudyNovember 15, 2023 Hyperbaric Oxygen Therapy for Soft Tissue Injury in Open Musculoskeletal Trauma: A Prospective Study. Cureus 15(11): e48848. doi:10.7759/cureus.48848
Chengzi Huang, Yilian Zhong, Chaochi Yue, Bin He, Yaling Li & Jun Li
The effect of hyperbaric oxygen therapy on the clinical outcomes of necrotizing soft tissue infections: a systematic review and meta-analysisWorld Journal of Emergency Surgery volume 18, Article number: 23 (2023)
Evan A. Tseros, Rithvik Reddy, Jacqueline Ho, Dakshika A. Gunaratne, Venkatesha Venkatesha, Faruque Riffat
Improvement in mortality with hyperbaric oxygen therapy in cervical necrotising fasciitis: a systematic review of the literatureAust J Otolaryngol 2023;6:8 | https://dx.doi.org/10.21037/
Ziye Bai, Huaigu Wang, Haobo Sun, Lei Cui
Effect of hyperbaric oxygen therapy on the patients with venous leg ulcer: A systematic review and meta-analysishttps://doi.org/10.1016/j.asjsur.2023.01.068
Flavia Tasmin Techera Antunes; Mariana Campos Duarte Machado; Alice Bartolomeu Garavini; Vanice Paula Ricardo Carvalho and Alessandra Hubner de Souza
The Effect of Hyperbaric Oxygen Therapy on Psychological State and Wound Healing: A Case Report
Virendrakumar Meena, Sitaram Barath, Shikhar Singh, Prateek Jakhar, Tarang Pate
Role of Imaging Spectrum Along With Other Diagnostic Modalities in Rhino-Orbital-Cerebral Mucormycosis (ROCM)Published: February 10, 2024, DOI: 10.7759/cureus.53962
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